| 品牌 | 货号 | 期货/现货 | 规格 | 价格 | 数量 |
|---|---|---|---|---|---|
| 阿拉丁 | E486554-1mg | 现货 | 1mg | 256.9 |
|
| 阿拉丁 | E486554-5mg | 现货 | 5mg | 728.9 |
|
| 阿拉丁 | E486554-25mg | 现货 | 25mg | 1872.9 |
|
| 阿拉丁 | E486554-100mg | 期货 | 100mg | 4631.9 |
|
| 英文别名 | TCO-NHS ester|1191901-33-3|TCO-NHS|(E)-Cyclooct-4-en-1-yl (2,5-dioxopyrrolidin-1-yl) carbonate|MFCD24386372|(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate|(E)-cyclooct-4-enyl 2,5-dioxopyrrolidin-1-yl carbonate|TCO-NHS Ester (equatorial)|2BX65M7XV6 |
|---|---|
| 规格或纯度 | ≥83.0% |
| 英文名称 | (E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate |
| 储存温度 | -20°C储存,充氩 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 | 应用 碳酸琥珀酰亚胺酯/NHS 官能化的环辛烯衍生物，用于将环辛烯部分掺入含胺化合物或生物分子中。环辛烯可用于与 1,2,4,5-四嗪进行菌株促进的无铜点击化学环加成反应。该环辛烯可与四嗪官能化化合物或生物分子反应，而不需要催化剂的存在，并可产生稳定的共价键。反式环辛烯和四嗪之间的 4+2 反电子需求 Diels-Alder 环加成反应是所报道的最快的生物相容性连接技术，并且在生物标记和成像中具有许多应用。（E）-环辛基-4-烯基 2,5-二氧杂-1-吡咯烷基碳酸酯可用于合成可与革兰氏阳性细菌细胞壁结合的万古霉素-TCO，随后可与四嗪（Tz）正交装饰磁性荧光纳米粒子反应。这种生物正交标记方法可用于检测革兰氏阳性细菌。 Description Succinimidyl carbonate/NHS functionalized cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging.(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate may be used in the synthesis of vancomycin-TCO that can bind to the cell wall of gram-positive bacteria, which can subsequently react with tetrazine (Tz) decorated magneto-fluorescent nanoparticles orthogonally. This bioorthogonal labeling method is useful for the detection of gram-positive bacteria. |
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