二氯乙酸

dichloroacetic acid

化合物简介

Dichloroacetic acid (DCA), sometimes called bichloroacetic acid (BCA), is the chemical compound with formula CHCl 2COOH. It is an acid, an analogue of acetic acid, in which 2 of the 3 hydrogen atoms of the methyl group have been replaced by chlorine atoms. Like the other chloroacetic acids, it has various practical applications. The salts and esters of dichloroacetic acid are called dichloroacetates. Salts of DCA have been studied as potential drugs because they inhibit the enzyme pyruvate dehydrogenase kinase.

基本信息

CAS：79-43-6
中文别名：二氯醋酸;
英文别名：Dichloroacetic acid;dichloraceticacid;dichloroacetic;dca(acid);dichloro;Urner\'s liquid;DKhUK;Acetic acid, dichloro-;dichloro-acetic acid;Dichloressigsure;bichloraceticacid;
分子式：C2H2Cl2O2
分子量：128.942
精确质量：127.943
Psa：37.3
Logp：0.8747

编号系统

MDL号：MFCD00004223
EINECS号：201-207-0

物化性质

外观与性状：透明无色至淡黄色液体
密度：1.563g/mLat 25°C(lit.)
沸点：194°C(lit.)
熔点：9-11°C(lit.)
闪点：>230°F
折射率：n20/D 1.466(lit.)
水溶解性：soluble
稳定性：Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents. Reacts with water. Protect from moisture. Hygroscopic.
储存条件：库房通风低温干燥,与氧化剂、碱类分开存放
蒸汽密度：4.5 (vs air)
蒸汽压：0.19 mm Hg ( 20 °C)

安全信息

RTECS号：AG6125000
安全说明：S26-S45-S61-S36/37-S36-S16
危险类别码：R35; R50
WGK Germany：2
海关编码：2915400090
危险品运输编码：UN 1764 8/PG 2
危险类别：8
包装等级：II
危险品标志：C
危险性描述：H315; H318; H335; H336; H351; H373; H400
信号词：Danger
危险标志：GHS05, GHS07, GHS08, GHS09
危险性防范说明：P261; P273; P280; P305 + P351 + P338

生产方法及用途

生产方法
1.醋酸氯化母液回收法由醋酸氯化得氯乙酸母液,氯乙酸母液在硫磺催化下,进行氯化反应,经蒸馏而得。
用途
1.用作有机合成中间体,用于制二氯乙酸甲酯(氯霉素中间体)和医药尿囊素及阳离子染料等。也用作腐蚀剂。